Miller Lab

Publications

Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma. Thadathil N, Selvarani R, Mohammed S, Nicklas EH, Tran AL, Kamal M, Luo W, Brown JL, Lawrence MM, Borowik AK, Miller BF, Van Remmen H, Richardson A, Deepa SS. Aging Cell. 2022 Jul 23. doi: 10.1111/acel.13676. Online ahead of print. PMID: 35869934 
Mechanotherapy Reprograms Aged Muscle Stromal Cells to Remodel the Extracellular Matrix during Recovery from Disuse. Hettinger ZR, Wen Y, Peck BD, Hamagata K, Confides AL, Van Pelt DW, Harrison DA, Miller BF, Butterfield TA, Dupont-Versteegden EE. Function (Oxf). 2022 Mar 24;3(3):zqac015. doi: 10.1093/function/zqac015. eCollection 2022. PMID: 35434632 
An In Vivo Stable Isotope Labeling Method to Investigate Individual Matrix Protein Synthesis, Ribosomal Biogenesis, and Cellular Proliferation in Murine Articular Cartilage. Kobak KA, Batushansky A, Borowik AK, Lopes EPB, Peelor Iii FF, Donovan EL, Kinter MT, Miller BF, Griffin TM. Function (Oxf). 2022 Feb 25;3(2):zqac008. doi: 10.1093/function/zqac008. eCollection 2022. PMID: 35399495
Antecedent Metabolic Health and Metformin (ANTHEM) Aging study: Rationale and study design for a randomized controlled trial. Kumari S, Bubak M, Schoenberg HM, Davidyan A, Elliehausen CJ, Kuhn KG, VanWagoner TM, Karaman R, Scofield RH, Miller BF, Konopka AR. J Gerontol A Biol Sci Med Sci. 2021 Dec 2:glab358. doi: 10.1093/gerona/glab358. Online ahead of print. PMID: 34865016
Necroptosis contributes to chronic inflammation and fibrosis in aging liver. Mohammed S, Thadathil N, Selvarani R, Nicklas EH, Wang D, Miller BF, Richardson A, Deepa SS. Aging Cell. 2021 Dec;20(12):e13512. doi: 10.1111/acel.13512. Epub 2021 Nov 11. PMID: 34761505 Free article.
Oklahoma Nathan Shock Aging Center - assessing the basic biology of aging from genetics to protein and function. Van Remmen H, Freeman WM, Miller BF, Kinter M, Wren JD, Chiao A, Towner RA, Snider TA, Sonntag WE, Richardson A. Geroscience. 2021 Oct;43(5):2183-2203. doi: 10.1007/s11357-021-00454-7. Epub 2021 Oct 4. PMID: 34606039 Free PMC article.
Determining the contributions of protein synthesis and breakdown to muscle atrophy requires non-steady-state equations. Kobak KA, Lawrence MM, Pharaoh G, Borowik AK, Peelor FF 3rd, Shipman PD, Griffin TM, Van Remmen H, Miller BF. J Cachexia Sarcopenia Muscle. 2021 Aug 21. doi: 10.1002/jcsm.12772. Online ahead of print. PMID: 34418329 
Systemic delivery of a mitochondria targeted antioxidant partially preserves limb muscle mass and grip strength in response to androgen deprivation. Rossetti ML, Dunlap KR, Salazar G, Hickner RC, Kim JS, Chase BP, Miller BF, Gordon BS. Mol Cell Endocrinol. 2021 Sep 15;535:111391. doi: 10.1016/j.mce.2021.111391. Epub 2021 Jul 7. PMID: 34245847
Age-Related Susceptibility to Muscle Damage Following Mechanotherapy in Rats Recovering From Disuse Atrophy. Hettinger ZR, Hamagata K, Confides AL, Lawrence MM, Miller BF, Butterfield TA, Dupont-Versteegden EE. J Gerontol A Biol Sci Med Sci. 2021 Nov 15;76(12):2132-2140. doi: 10.1093/gerona/glab186. PMID: 34181006
  A Novel Stable Isotope Approach Demonstrates Surprising Degree of Age-Related Decline in Skeletal Muscle Collagen ProteostasisClaire B Abbott, Marcus M Lawrence, Kamil A Kobak, Erika Barboza Prado Lopes, Frederick F Peelor, III, Elizabeth J Donald, Holly Van Remmen, Timothy M Griffin, Benjamin F Miller, , Function, Volume 2, Issue 4, 2021, zqab028, https://doi.org/10.1093/function/zqab028
  Tumor burden negatively impacts protein turnover as a proteostatic process in non-cancerous liver, heart, and muscle, but not brain. Brown JL, Lawrence MM, Borowik A, Oliver L, Peelor Iii FF, Van Remmen H, Miller BF. J Appl Physiol (1985). 2021 May 20. doi: 10.1152/japplphysiol.01026.2020. Online ahead of print. PMID: 34013745
Massage as a Mechanotherapy for Skeletal Muscle. Van Pelt DW, Lawrence MM, Miller BF, Butterfield TA, Dupont-Versteegden EE. Exerc Sport Sci Rev. 2021 Apr 1;49(2):107-114. doi: 10.1249/JES.0000000000000244. PMID: 33720912
The ketogenic diet preserves skeletal muscle with aging in mice. Wallace MA, Aguirre NW, Marcotte GR, Marshall AG, Baehr LM, Hughes DC, Hamilton KL, Roberts MN, Lopez-Dominguez JA, Miller BF, Ramsey JJ, Baar K. Aging Cell. 2021 Apr;20(4):e13322. doi: 10.1111/acel.13322. Epub 2021 Mar 6. PMID: 33675103 Free PMC article.
Physiologic Responses to Dietary Sulfur Amino Acid Restriction in Mice Are Influenced by Atf4 Status and Biological Sex. Jonsson WO, Margolies NS, Mirek ET, Zhang Q, Linden MA, Hill CM, Link C, Bithi N, Zalma B, Levy JL, Pettit AP, Miller JW, Hine C, Morrison CD, Gettys TW, Miller BF, Hamilton KL, Wek RC, Anthony TG. J Nutr. 2021 Apr 8;151(4):785-799. doi: 10.1093/jn/nxaa396. PMID: 33512502 Free PMC article.
Ribosome biogenesis and degradation regulate translational capacity during muscle disuse and reloading. Figueiredo VC, D'Souza RF, Van Pelt DW, Lawrence MM, Zeng N, Markworth JF, Poppitt SD, Miller BF, Mitchell CJ, McCarthy JJ, Dupont-Versteegden EE, Cameron-Smith D. J Cachexia Sarcopenia Muscle. 2021 Feb;12(1):130-143. doi: 10.1002/jcsm.12636. Epub 2020 Nov 24. PMID: 33231914 
  Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia. Chucair-Elliott AJ, Ocañas SR, Stanford DR, Ansere VA, Buettner KB, Porter H, Eliason NL, Reid JJ, Sharpe AL, Stout MB, Beckstead MJ, Miller BF, Richardson A, Freeman WM. Commun Biol. 2020 Nov 19;3(1):693. doi: 10.1038/s42003-020-01418-x. PMID: 33214681 
Cancer cachexia in a mouse model of oxidative stress. Brown JL, Lawrence MM, Ahn B, Kneis P, Piekarz KM, Qaisar R, Ranjit R, Bian J, Pharaoh G, Brown C, Peelor FF 3rd, Kinter MT, Miller BF, Richardson A, Van Remmen H. J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1688-1704. doi: 10.1002/jcsm.12615. Epub 2020 Sep 12. PMID: 32918528 Free PMC article.
Exercise-Pharmacology Interactions: Metformin, Statins, and Healthspan. Miller BF, Thyfault JP. Physiology (Bethesda). 2020 Sep 1;35(5):338-347. doi: 10.1152/physiol.00013.2020. PMID: 32783612
Wolff CA, Lawrence MM, Porter H, Zhang Q, Reid JJ, Laurin JL, Musci RV, Linden MA, Peelor FF 3rd, Wren JD, Creery JS, Cutler KJ, Carson RH, Price JC, Hamilton KL, Miller BF. Sex differences in changes of protein synthesis with rapamycin treatment are minimized when metformin is added to rapamycin. Geroscience. 2020 Aug 5. doi: 10.1007/s11357-020-00243-8. Online ahead of print. PMID: 32761290.
Lawrence MM, Van Pelt DW, Confides AL, Hunt ER, Hettinger ZR, Laurin JL, Reid JJ, Peelor FF 3rd, Butterfield TA, Dupont-Versteegden EE, Miller BF. Massage as a mechanotherapy promotes skeletal muscle protein and ribosomal turnover but does not mitigate muscle atrophy during disuse in adult rats. Acta Physiol (Oxf) 229:e13460, 2020.
Lawrence MM*, Van Pelt DW*, Confides AL, Hettinger ZR, Hunt ER, Reid JJ, Laurin JL, Peelor FF 3rd, Butterfield TA, Miller BF, Dupont-Versteedgen EE. Muscle from aged rats is resistant to mechanotherapy during atrophy and reloading. Geroscience (June 25, 2020), online ahead of print.
Groennebaek T, Nielsen J, Jespersen NR, Bøtker HE, de Paoli FV, Miller BF, Vissing K. Utilization of biomarkers as predictors of skeletal muscle mitochondrial content after physiological intervention and in clinical settings. Am J Physiol Endocrinol Metab. 2020 Jun 1;318(6):E886-E889. doi: 10.1152/ajpendo.00101.2020. Epub 2020 Apr 7. PMID: 32255679
Brown JL, Lawrence MM, Ahn B, Kneis P, Piekarz KM, Qaisar R, Ranjit R, Bian J, Pharaoh G, Brown C, Peelor FF 3rd, Kinter MT, Miller BF, Richardson A, Van Remmen H. Cancer cachexia in a mouse model of oxidative stress. J Cachexia Sarcopenia Muscle (accepted July 7, 2020).
Van Pelt DW, Vechetti IJ Jr, Lawrence MM, Van Pelt KL, Patel P, Miller BF, Butterfield TA, Dupont-Versteegden EE. Serum extracellular vesicle miR-203a-3p content is associated with skeletal muscle mass and protein turnover during disuse atrophy and regrowth. Am J Physiol Cell Physiol (July 8 2020), online ahead of print.
Ehrlicher SE, Stierwalt HD, Miller BF, Newsom SA, Robinson MM. Mitochondrial adaptations to exercise do not require Bcl2-mediated autophagy but occur with BNIP3/Parkin activation. FASEB J. 2020 Mar;34(3):4602-4618. doi: 10.1096/fj.201902594RR. Epub 2020 Feb 6. PMID: 32030805
Miller BF, Reid JJ, Price JC, Lin HL, Atherton PJ, Smith K. CORP: The use of deuterated water for the measurement of protein synthesis.J Appl Physiol (1985). 2020 May 1;128(5):1163-1176. doi: 10.1152/japplphysiol.00855.2019. Epub 2020 Mar 26. PMID: 32213116
Piekarz KM, Bhaskaran S, Sataranatarajan K, Street K, Premkumar P, Saunders D, Zalles M, Gulej R, Khademi S, Laurin J, Peelor R, Miller BF, Towner R, Van Remmen H. Molecular changes associated with spinal cord aging. Geroscience. 2020 Apr;42(2):765-784. doi: 10.1007/s11357-020-00172-6. Epub 2020 Mar 6.PMID: 32144690 
Wolff CA, Reid JJ, Musci RV, Linden MA, Konopka AR, Peelor FF, Miller BF, Hamilton KL. Differential Effects of Rapamycin and Metformin in Combination with Rapamycin on Mechanisms of Proteostasis in Cultured Skeletal Myotubes. J Gerontol A Biol Sci Med Sci. 2019. PMID: 30820523
Miller BF, Baehr LM, Musci RV, Reid JJ, Peelor FF 3rd, Hamilton KL, Bodine SC. Muscle-specific changes in protein synthesis with aging and reloading after disuse atrophy. J Cachexia Sarcopenia Muscle. 2019 Dec;10(6):1195-1209. doi: 10.1002/jcsm.12470. Epub 2019 Jul 16. PMID: 31313502 Free PMC Article
Linden M.A., Ross T.T., Beebe D.A., Gorgoglione M.F., Hamilton K.L., Miller B.F., Braun B., Esler W.P. 2019. Interaction between an SGLT2 inhibitor and exercise training. Metabolism. May 24. [Epub ahead of print]. PMID: 31132381  
Reid JJ, Linden MA, Peelor FF, Miller RA, Hamilton KL, Miller BF. Brain Protein Synthesis Rates in the UM-HET3 Mouse Following Treatment with Rapamycin or Rapamycin with Metformin. J Gerontol A Biol Sci Med Sci. 2019. PMID: 30864661
Miller B.F., Pharaoh G.A., Hamilton K.L., Peelor F.F., Kirkland J.L., Freeman W.M., Mann S.N., Kinter M., Price J.C., Stout M.B. 2019. Short-term calorie restriction and 17α-estradiol administration elicit divergent effects on proteostatic processes and protein content in metabolically active tissues. J Gerontol A Biol Sci Med Sci. 2019 May 10. [Epub ahead of print]. PMID: 31074767.    
Laurin, J.L., Reid, J.J., Lawrence, M.M., and Miller B.F*. Long-Term Aerobic Exercise Preserves Muscle Mass and Function with Age. 2019. Current Opinions in Physiology. 10:70–74. doi.org/10.1016/j.cophys.2019.04.019
Miller, B. F., Hamilton, K. L., Majeed, Z. R., Abshire, S. M., Confides, A. L., Hayek, A. M., Hunt, E.R., Shipman, P., Peelor, F.F., Butterfield, T.A. and E.E. Dupont-Versteegden. (2018). Enhanced skeletal muscle regrowth and remodelling in massaged and contralateral non-massaged hindlimb. The Journal of Physiology, 596(1), 83–103. PMID: 29090454. PMCID: PMC5746529.
Konopka AR, Laurin JL, Schoenberg HM, Reid JJ, Castor WM, Wolff CA, Musci RV, Safairad OD, Linden MA, Biela LM, Bailey SM, Hamilton KL, Miller BF. Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. Aging Cell. 2018 Dec 11:e12880. doi: 10.1111/acel.12880. [Epub ahead of print] PMID: 30548390
Miller BF, Seals DR, Hamilton KL. A viewpoint on considering physiological principles to study stress resistance and resilience with aging. Ageing Res Rev. 2017 Sep;38:1–5. PMID: Abstract
Hamilton KL, and Miller BF. Mitochondrial proteostasis as a shared characteristic of slowed aging: the importance of considering cell proliferation. The Journal of Physiology. 2017. 595(20):6401-6407. PMID: Abstract
Miller BF, Drake JC, Naylor B, Price JC, Hamilton KL. The measurement of protein synthesis for assessing proteostasis in studies of slowed aging. Ageing Res Rev. 2014 Nov;18:106-11. PMCID: PMC4258117
Drake JC, Peelor FF, Biela LM, Watkins MK, Miller RA, Hamilton KL, Miller BF. Assessment of mitochondrial biogenesis and mTORC1 signaling during chronic rapamycin feeding in male and female mice. J Gerontol A Biol Sci Med Sci. 2013 Dec;68(12):1493–501. PMCID: PMC3814233
Miller BF, Hamilton KL. A perspective on the determination of mitochondrial biogenesis. Am J Physiol Endocrinol Metab. 2012 Mar 1;302(5):E496–9. PMCID: PMC3311289